![]() In view of the gaps in sensitivity and accuracy and the importance of precise diagnosis to prevent maternal and fetal complications, there is still the need to find other affordable, more sensitive and more accurate biochemical marker/s that will help in diagnosing PROM especially in difficult cases.Ĭreatinine nitrazine specificity sensitivity urea.Ĭopyright: © International Journal of Health Sciences. This was followed by creatinine and then urea. NUOLUX Ph Paperlitmus Testing Indicator Acid Universal Level Nitrazine Test Checking Tool Neutral Strip Accessories Watermeter, Delivery 1-2 Weeks. ![]() Nitrazine strip was the most reliable of the three in the diagnosis of PROM. Predictive ability of urea at >12.7 mg/dl obtained as cutoff value from the ROC curve showed a sensitivity of 19.64% and specificity of 94.44% while for creatinine the cutoff value was at >0.8 mg/dl with sensitivity of 48.21% and specificity of 65.28%. Nitrazine test showed high level of specificity (100%) but a sensitivity of 87.5%. Statistical analysis was done using SPSS version 23.0 and setting statistical significance at P ≤ 0.05. Receiver Operating Characteristic (ROC) curves were plotted to determine cutoff values for urea and creatinine. Vaginal fluid aspirates from both groups of patient were tested for urea, creatinine, and pH levels using nitrazine strip. ![]() Sixty-four pregnant women with demonstrable passage or pooling of liquor par vaginum on speculum examination and 64 with no liquor drainage at 28-42 weeks gestation were studied. Nitrazine strip measures pH levels while urea and creatinine are produced mainly in amniotic fluid and not in the maternal vagina. These tiny ruptures cannot be detected with traditional methods, but are clinically relevant as they can induce delivery, cause infections, and threaten the health of both mother and child.īecause Actim PROM is specific to amniotic fluid IGFBP-1, tests can be completed even in the presence of blood and other bodily fluids, infections, and medical products.The study compared the reliability of nitrazine, urea, and creatinine in the diagnosis of premature rupture of membrane (PROM). Thanks to its high sensitivity, Actim PROM detects even low concentrations of IGFBP-1 caused by micro-ruptures in the fetal membrane. Actim PROM detects IGFBP-1 in vaginal swab samples and helps to identify membrane ruptures. Amniotic fluid is normally not found in the vagina, but when fetal membranes rupture, amniotic fluid leaks into the vagina and the IGFBP-1 concentration quickly rises and remains high until delivery. How Actim prom works Actim ® PROM and Vaginal IGFBP-1Īctim PROM rapid test is based on highly specific monoclonal antibodies that bind to the insulin-like growth factor binding protein-1 (IGFBP-1) present in amniotic fluid in high amounts. Actim PROM is available in multiple package sizes.The test kit contains all the materials required to perform the test and it can be stored at room temperature.The test results are not affected by blood, intercourse, semen, urine, vaginal medications, bathing products, or infections.Actim PROM is an easy-to-use one-step dipstick test that gives test results at the bedside in just 5 minutes, with sampling completed in seconds – with or without speculum.The test can be performed at any gestational age.Actim PROM is a rapid test that reliably detects PROM, even before any clinically visible signs can be detected.
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